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RESEARCH PROGRAMME

Research work in Division of Medical Physics is being developed along two lines:
Electron Paramagnetic Resonance - EPR, its possibilities and applications
medical physics, and in particular the new method: NURSE-ECG in diagnostics of heart diseases


The Division is equipped with::
EPR spectrometer made by Bruker type EMX {X-band, 9.4 GHz) - detail information are given on the website EPR/ENDOR Laboratory
EPR spectrometer (Q-band, 35 GHz)
equipment for computer analysis of ECG records
equipment for the cardiac muscle examination by the Holter Method
ultrasonographic unit
ELECTRON PARAMAGNETIC RESONANCE
Electron paramagnetic resonance (EPR) is a spectroscopic method allowing investigation of substances containing paramagnetic centres, such as:
transition metal ions and rare earth ions with incomplete shells: 3d, 4d, 4f, 5d, 5f,
radicals of natural origin,
radicals generated by irradiation with X, gamma or UV radiation,
certain type defects in the crystal lattice in solids.

EPR is characterised by:
high sensitivity,
short time of single measurement,
simple preparation of samples to be measured.
The method has been succesfully applied in such fields as physics, chemistry, biology, medicine and geology.

At the Division of Medical Physics the method has been used for:
investigation of structure and electron dynamics in:
tissues
biologically active compounds such as
- steroid hormones
- vitamins
- antibiotics and other drugs
food products
- cofee
- tea
tobacco
dating of geological materials (fossil teeth and bones of cave bear and mammoth) and archaeological artefacts (ceramics).

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HIGH RESOLUTION ELECTROCARDIOGRAPHY
The Numerical Signal Resolution Enhancement Electrocardiography (NURSE-ECG) is a new method for diagnosis of the cardiac muscle ischaemia, devised at the Division of Medical Physics by Professor Ryszard Krzyminiewski.
The method allows detection of even relatively small changes in the process of the cardiac muscle depolarisation.
In a fast, cheap and non-invasive manner provides information about local ischaemia of the cardiac muscle; the sensivity and resolution of the method make it possible to identify the changes even in patients whose standard and exercise ECG as well as echocardiography do not show apparent deviations from the standard records.
The method also allows detection of changes caused by drug administration so it excellent tool for clinical therapy control.
The sensitivity of the method in diagnosis of the cardiac muscle ischaemia is comparable with that of coronarography and emission tomography .
An additional benefit it ensures is the possibility of observation of dynamics of the depolarisation.
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Last modified: 23.02.2006